Pax7-SUMOylation and neural crest development
نویسندگان
چکیده
منابع مشابه
Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice.
Pax7 is a member of the paired box containing gene family. Its expression pattern suggests a function in cephalic neural crest derivatives, skeletal muscle and central nervous system development. To understand the role of Pax7 during mouse embryogenesis, we used the homologous recombination technique in embryonic stem cells and generated Pax7-/- mice. Homozygous animals are born but die shortly...
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BACKGROUND Neural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage. Abnormal development of the neural crest is associated with several human maladies including cleft/lip palate, aggressive cancers such as melanoma and neuroblastoma, and rare syndromes, like Wa...
متن کاملPax7 identifies neural crest, chromatophore lineages and pigment stem cells during zebrafish development.
Using immunostaining during early zebrafish embryogenesis, we report that the cranial and trunk neural crest expresses the paired box protein Pax7, thus revealing a novel neural crest marker in zebrafish. In the head, we show that Pax7 is broadly expressed in the cranial crest cells, which indicates that duplication of the paralogous group Pax3/7 at the origin of vertebrates included the conser...
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(E12) and localise to embryonic hair follicles between E13.5 and E16.5. Little is known about the kinetics of melanoblast migration and localisation to the developing hair follicle because of the difficulty of imaging live embryonic skin. Culture of embryonic skin is technically challenging because of the requirement for an air–liquid-interface (ALI) in order for the tissue to develop. Historic...
متن کاملSoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation.
Sox9 and the closely related factor Sox10 are essential for the formation of neural crest precursor cells, and play divergent roles in the process by which these cells are subsequently directed to form specific derivatives. These group E Sox factors have also been implicated in the development of the vertebrate inner ear. Despite their importance, however, the mechanisms that allow SoxE protein...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2009
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2009.05.501